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WHO ESSENTIAL DRUGS LIST INCLUSION OF …

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内容提示: 1From: LOA Thanni [mailto:loathanni@] Sent: 04 October 2010 20:18To: emlsecretariatSubject: WHO essential medicines section - 18th expert committee meetingWHO, Essential Medicines Section,WHO ESSENTIAL DRUGS LIST – INCLUSION OF TRANEXAMIC ACIDI write this letter for the 18th Expert Committee meeting to considerfavourably, the inclusion of TRANEXAMIC ACID on the essential drugslist. This will ensure that governments, especially of developingcountries like Nigeria, facilitates the availability of the drug ...

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1From: LOA Thanni [mailto:loathanni@] Sent: 04 October 2010 20:18To: emlsecretariatSubject: WHO essential medicines section - 18th expert committee meetingWHO, Essential Medicines Section,WHO ESSENTIAL DRUGS LIST – INCLUSION OF TRANEXAMIC ACIDI write this letter for the 18th Expert Committee meeting to considerfavourably, the inclusion of TRANEXAMIC ACID on the essential drugslist. This will ensure that governments, especially of developingcountries like Nigeria, facilitates the availability of the drug inthe country, thus ensuring that the cost is reduced.Trauma is a major cause of morbidity and mortality in Nigeria. In myTeaching Hospital Accident and Emergency centre, patient attendance is1000 to 3000 annually. Trauma is responsible for over 70% of surgicalcases mostly arising from road traffic injuries. Mortality from severeinjuries is over 30% at our centre.Tranexamic acid was not in use in our centre until 2005 when we becameinvolved in the CRASH-2 study of tranexamic acid use in traumapatients with clinically significant haemorrhage. At the conclusion ofthe trial, the drug was found to significantly reduce mortality fromtrauma related haemorrhage. Completion of the study has alsoterminated our supply of the drug. Despite extensive effort, we havefound only one company that markets the drug but it is relativelyexpensive at the dose of 2g over 8hrs IV per adult patient that wecurrently use.It is hoped that this letter finds favourable considerationThank youReferences1. L.O.A. Thanni, O.A. Kehinde. Trauma at a Nigerian teachinghospital: pattern and documentation of presentation. African HealthSciences 2006; 6(2): 103-1062. CRASH-2 trial collaborators. Effects of tranexamic acid on death,vascular occlusiveevents, and blood transfusion in trauma patients with significanthaemorrhage (CRASH-2): a randomised, placebo-controlled trial. TheLancet july 2010; 376(9734): 23 - 32L.O.A. Thanni. FWACSAssociate professor / Consultant SurgeonHead, Dept of Orthopaedics and TraumatologyOlabisi Onabanjo University and Teaching HospitalSagamu, Ogun StateNIGERIA

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